I use lots of medical analogies when I explain the stock issues. Here's what I would chip in as the answer to this question.
I always explain significance as "how big, how bad?" Some people even separate the issue into those two dimensions: degree
is how big, how widespread? If you have chronic pain, is it in your little toe, or throughout your body? If you've got an outbreak of bird flu, is it one patient or all of New York City? Harm
, "how bad," is distinct from "how big." Ebola is pretty bad on the "how bad" scale: it's effectively incurable, untreatable, and absent a miracle you die spurting blood from every opening. The opposite end might be the common cold, which isn't remotely life threatening; a few days' discomfort and that's it.
Inherency, then, also has two dimensions: how long and how controlled? The common cold isn't terribly inherent, because it goes away on its own in two or three days. It's literally more rational to do nothing and wait for it to go away than it is to treat it, beyond simple things like fluids and rest. That's a good analogy for voting negative: do nothing and wait for it to go away. Another minimally inherent need is a chronic medical condition that doesn't ever
go away on its own, but is 100% controllable by an outside agency, such as the majority of cases of diabetes: control the diet, get good exercise, monitor blood sugar and take insulin when needed, and the condition is controlled. In that case, is radical action, like an experimental pancreas transplant, warranted? Probably not; a regimen already in place controls the condition, and the disadvantages of major surgery and an organ transplant outweigh the non-inherent advantage. In each case, the question we're answering is, "Absent change, will this phenomenon persist long enough to cause unacceptable damage?" If it goes away on its own while the cumulative damage is still minimal, then no. If it's sufficiently controlled that it's not piling up discernible harm, then no.
Of course, as Delta_FC notes, you can't answer either question unless you isolate the cause of the problem. If all you know are the symptoms, then you don't know how long the problem can be expected to persist, nor how controllable it is. I had more to say about that here
Hope they're in slightly better focus.